Elliot Moore (Mark Wahlberg) is a high school teacher living in Philadelphia. He and his wife Alma (Zooey Deschanel), have been having problems and their marriage is falling apart. As an escape, he wraps his life around science. As he lectures to his students about theory's behind the disappearance of honey bees, strange things begin to happen outside in a near by city. It's decided that everyone will leave school and flee the city before they are affected too.
Elliot leaves for home to get his wife and pack a few things to leave the city. They meet up with their friend Julian (John Leguizamo), and his daughter, Jess (Ashlyn Sanchez). It's decided the best way out is by train. But as the train stops at one last small town, they can go no further or they will be driving into their own demise. Something is affecting the people in large cities to cause fatal chemical imbalances in their brains. Now they much try and make their way out of the city in time before the happening effects them all.
20th Century Fox
Director: M. Night Shyamalan
Writer: M. Night Shyamalan
Producer: Barry Mender, Barry Mendel, M. Night Shyamalan