"Miss" Chloe (voice - Drew Barrymore), is one pampered chihuahua, who's not only adorned by a diamond collar but also wears Prada as wealthy owner, "Aunt" Viv (Jamie Lee Curtis), gives her nothing but the finest. Viv goes on an exotic retreat and leaves her pride and joy with her niece Rachel (Piper Perabo). Sam Cortez (Manolo Cardona) is the gardener at the mansion and along with his chihuahua pooch Papi (voice - George Lopez), the are minding the outside of the home while Viv is away. Papi, has a thing for Chloe but she can't be bothered with the hired help. When Rachel isn't happy just laying around the mansion in Beverly Hills, her girlfriends talk her into taking a road trip to Cabo. With Chloe in hand, the girls set off to soak up the sunny shores of Mexico.
While the girls are away from the hotel, they leave Chloe all alone with a regular can of dog food which Chloe finds repulsive and when she leaves the hotel to find Rachel, she is picked up by a dog snacther and taken to a dog fighting ring where she will face off against bloodthirsty Doberman, El Diablo (Edward James Olmos). Delgado (voice - Andy Garcia) a German Shepard will help Chloe get out of this mess but not before she gets into more trouble with Manuel the shifty rat (voice - Cheech Marin) and his sidekick Chico (voice - Paul Rodriguez), the iguana. But love struck Papi will track her scent and help bring Chloe safely home before Viv knows what happened.
Buena Vista Pictures Distribution, Walt Disney Studios Motion Pictures
Director: Raja Gosnell
Writers: Analisa LaBianco, Jeff Bushell
Producers: Todd Lieberman, David Hoberman, John L. Jacobs